Effects of substrate stiffness on the viscoelasticity and migration of prostate cancer cells examined by atomic force microscopy

• Xiaoqiong Tang,
• Yan Zhang,
• Jiangbing Mao,
• Yuhua Wang,
• Zhenghong Zhang,
• Zhengchao Wang and
• Hongqin Yang

Beilstein J. Nanotechnol. 2022, 13, 560–569, doi:10.3762/bjnano.13.47

• substrate stiffness and the mechanical properties of cells in prostate tumour metastasis, providing a basis for understanding the changes in the biomechanical properties at a single-cell level. Keywords: actin cytoskeleton; atomic force microscopy; migration; prostate cancer cells; substrate stiffness

• metastasis and possible regulatory mechanisms, which can further guide the study and treatment of cancer metastasis. Results and Discussion Effect of substrate stiffness on the migration of prostate cancer cells In order to investigate the mechanical properties and metastatic ability of human prostate cancer

• migration capacity, and cells on soft substrates (3 kPa) had the lowest migration capacity (Figure 2c). Cell proliferation assays also revealed that both cell lines had a significantly greater ability to proliferate on stiff substrates, and that the proliferation of prostate cancer cells significantly

Comprehensive review on ultrasound-responsive theranostic nanomaterials: mechanisms, structures and medical applications

• Sepand Tehrani Fateh,
• Lida Moradi,
• Elmira Kohan,
• Michael R. Hamblin and
• Amin Shiralizadeh Dezfuli

Beilstein J. Nanotechnol. 2021, 12, 808–862, doi:10.3762/bjnano.12.64

• . reported that when the distance between the cell and the MB was increased to 5.5 µm, the exerted shear stress on the cell membrane suddenly decreased [78]. Schlicher et al. exposed prostate cancer cells (DU145) to 24 kHz US irradiation to investigate the cavitation events and the changes in the cell

• isothiocyanate (FITC)-labeled bovine serum albumin (BSA), FITC-labeled 150, 500, and 2000 kDa dextrans into DU145 prostate cancer cells. They blocked the endocytosis mechanism to assess whether the endocytic pathway was upregulated during US exposure. They showed that all of these fluorescent molecules were

The impact of molecular tumor profiling on the design strategies for targeting myeloid leukemia and EGFR/CD44-positive solid tumors

• Nikola Geskovski,
• Nadica Matevska-Geshkovska,
• Simona Dimchevska Sazdovska,
• Marija Glavas Dodov,
• Kristina Mladenovska and
• Katerina Goracinova

Beilstein J. Nanotechnol. 2021, 12, 375–401, doi:10.3762/bjnano.12.31

Advanced hybrid nanomaterials

• Andreas Taubert,
• Fabrice Leroux,
• Pierre Rabu and
• Verónica de Zea Bermudez

Beilstein J. Nanotechnol. 2019, 10, 2563–2567, doi:10.3762/bjnano.10.247

• nanoparticles [34]. The resulting gold–alendronate nanoplatform combines antitumor activity through drug delivery and photothermal therapy, as illustrated in vitro on the inhibition of prostate cancer cells. In the field of hybrid coordination networks, new lanthanide-based networks synthesized by a solvo

Use of data processing for rapid detection of the prostate-specific antigen biomarker using immunomagnetic sandwich-type sensors

• Camila A. Proença,
• Tayane A. Freitas,
• Thaísa A. Baldo,
• Elsa M. Materón,
• Flávio M. Shimizu,
• Gabriella R. Ferreira,
• Frederico L. F. Soares,
• Ronaldo C. Faria and
• Osvaldo N. Oliveira Jr.

Beilstein J. Nanotechnol. 2019, 10, 2171–2181, doi:10.3762/bjnano.10.210

• ) and prostate cancer cells (LNCap). Parallel coordinates plot for PSA concentrations from 12.5 to 1111 fg·mL−1 after the feature-selection procedure. The x-axis represents time values, while the y-axis represents Euclidean distances related to the current. IDMAP plot obtained from the data in Figure 1A

• for buffers containing different PSA concentrations and from Figure 3 for prostate cancer cells. In both cases, feature selection was applied before plotting the data. Schematic illustration of the fabrication of sandwich-type electrochemical immunosensors (INμ-SPCEs). Electrode modification with 10

Synthesis and potent cytotoxic activity of a novel diosgenin derivative and its phytosomes against lung cancer cells

• Liang Xu,
• Dekang Xu,
• Ziying Li,
• Yu Gao and
• Haijun Chen

Beilstein J. Nanotechnol. 2019, 10, 1933–1942, doi:10.3762/bjnano.10.189

• anticancer activities, such as restraining the hTERT gene expression in A549 lung cancer cells [3], inhibiting breast cancer stem-like cells via Wnt β-catenin signaling [4], impeding hepatocellular carcinoma cells by increasing DDX3 expression [5], and inducing apoptosis of prostate cancer cells through

Targeting strategies for improving the efficacy of nanomedicine in oncology

• Gonzalo Villaverde and
• Alejandro Baeza

Beilstein J. Nanotechnol. 2019, 10, 168–181, doi:10.3762/bjnano.10.16

• efficient in vitro treatment of human prostate cancer cells. The excellent performance could be explained by the multivalence effect. The fact of having the same ligand interacting with the same receptor simultaneously without any other non-specific interaction from the other ligand maximized the

Hybrid Au@alendronate nanoparticles as dual chemo-photothermal agent for combined cancer treatment

• Anouchka Plan Sangnier,
• Romain Aufaure,
• Laurence Motte,
• Claire Wilhelm,
• Erwann Guenin and
• Yoann Lalatonne

Beilstein J. Nanotechnol. 2018, 9, 2947–2952, doi:10.3762/bjnano.9.273

• under irradiation within the first biological window (650–900 nm). The Au@alendronate nanoplatform thus provided a combined antitumor activity through drug delivery and photothermal therapy. Au@alendronate NPs inhibited in vitro the proliferation of prostate cancer cells (PC3) in a dose-dependent manner

Cationic PEGylated polycaprolactone nanoparticles carrying post-operation docetaxel for glioma treatment

• Cem Varan and
• Erem Bilensoy

Beilstein J. Nanotechnol. 2017, 8, 1446–1456, doi:10.3762/bjnano.8.144

• effective on growth inhibition of breast and prostate cancer cells when compared to free docetaxel [23]. Core–shell nanoparticles are also used as non-viral vectors for the treatment of glioma. Zamora et al. prepared photochemical internalization mediated polyamine core–shell nanoparticles for tumor

Carbon nanomaterials sensitize prostate cancer cells to docetaxel and mitomycin C via induction of apoptosis and inhibition of proliferation

• Kati Erdmann,
• Jessica Ringel,
• Silke Hampel,
• Manfred P. Wirth and
• Susanne Fuessel

Beilstein J. Nanotechnol. 2017, 8, 1307–1317, doi:10.3762/bjnano.8.132

• . Co-administration of chemotherapeutics with carbon nanomaterials could result in a reduction of the chemotherapeutic dosage and thus limit systemic side effects. Keywords: carbon nanomaterials; chemosensitization; docetaxel; mitomycin C; prostate cancer cells; Introduction According to the global

Multiwalled carbon nanotube hybrids as MRI contrast agents

• Nikodem Kuźnik and
• Mateusz M. Tomczyk

Beilstein J. Nanotechnol. 2016, 7, 1086–1103, doi:10.3762/bjnano.7.102

• period, is consistent with the abovementioned toxicity studies. Cytotoxicity and hemolysis Cytotoxicity of the nanohybrids was studied on various cell types (HeLa, HEK 293, human prostate cancer cells PC3, fibroblasts and others) and a general conclusion is the dose-dependent trend. However, the

Overview about the localization of nanoparticles in tissue and cellular context by different imaging techniques

• Anja Ostrowski,
• Daniel Nordmeyer,
• Alexander Boreham,
• Cornelia Holzhausen,
• Lars Mundhenk,
• Christina Graf,
• Martina C. Meinke,
• Annika Vogt,
• Sabrina Hadam,
• Jürgen Lademann,
• Eckart Rühl,
• Ulrike Alexiev and
• Achim D. Gruber

Beilstein J. Nanotechnol. 2015, 6, 263–280, doi:10.3762/bjnano.6.25

• deposits in HE-stained sections of glioblastomas (Figure 1a), a common brain tumor with high clinical relevance [45]. Such particles have similarly been visualized after targeting prostate cancer cells in humans [46]. Iron oxide nanoparticles have been introduced as diagnostic tool or for the treatment of

Synthesis of boron nitride nanotubes and their applications

• Saban Kalay,
• Zehra Yilmaz,
• Ozlem Sen,
• Melis Emanet,
• Emine Kazanc and
• Mustafa Çulha

Beilstein J. Nanotechnol. 2015, 6, 84–102, doi:10.3762/bjnano.6.9

• composites in the presence and absence of a magnetic field [84]. The BNNT–NaGdF4:Eu composites simultaneously show fluorescent and magnetic properties. Thus, imaging and targeting of the composites can be more easily achieved. Human LNCaP prostate cancer cells were treated with the BNNT–NaGdF4:Eu composites

• in the presence and absence of a magnetic field and higher cell-associated uptake was found in the presence of a magnetic field. Then, the composites were loaded with doxorubicin (dox) to investigate the viability of LNCaP prostate cancer cells in the magnetic field. It was found that dox-loaded BNNT

• pH dependent and both negatively and positively charged structures had the same dox loading capacity. The BNNT–MS–NH2 had higher uptake potential in LNCaP prostate cancer cells due to its charge. Thus, it had a higher toxicity towards LNCaP prostate cancer cells. It was concluded that the prepared

Nanodiamond-DGEA peptide conjugates for enhanced delivery of doxorubicin to prostate cancer

• Amanee D Salaam,
• Patrick Hwang,
• Roberus McIntosh,
• Hadiyah N Green,
• Ho-Wook Jun and
• Derrick Dean

Beilstein J. Nanotechnol. 2014, 5, 937–945, doi:10.3762/bjnano.5.107

• collagens, laminins, E-cadherin, and matrix metalloproteinase 1 [31]. α2β1 integrins have been proven to be up-regulated in bone metastatic prostate cancer cells [32][33]. Particularly, PC3 human bone metastatic prostate cancer cell lines have the highest expression of α2β1 integrins when compared to other

• , targeting and drug delivery). We show significantly improved efficacy and toxicity of DOX by using ND-DGEA conjugates to deliver DOX therapy to prostate cancer cells. Experimental Materials All materials, buffers, and reagents were purchased and used as received. ND hard gel (≈20% water) was purchased from

• ) was used to measure the zeta potential and hydrodynamic size of the ND before and after modification with DGEA and DOX; samples were prepared at a concentration of 200 µg/mL. Cell culture Human bone metastatic prostate cancer cells (PC3) and mesenchymal stem cells (hMSC) were acquired from American